Drs. Connie Weaver, Foods and Nutrition and Mario Ferruzzi, Food Science have teamed up with researchers across the country to form the Center for Research in Alternative and Complementary Medicine in Alzheimer's disease research located at the Mount Sinai School of Medicine (MSSM).
Currently, it is estimated that five million people in the United States suffer from Alzheimer's disease, with the number projected to reach 11 to 16 million by the year 2050. However, delaying the onset of Alzheimer's disease by five years is estimated to potentially reduce the number of projected cases by 50 percent.
The center will be focusing on studying grape-derived polyphenols and their potential for prevention and/or treatment of Alzheimer's disease. A characteristic hallmark of Alzheimer's disease-type neuropathology is the accumulation of beta-amyloid peptides and their formation into plaques in the brain. Researchers have found that polyphenol extracts from Cabernet Sauvignon and Concord grape juice reduced the generation and accumulation of beta-amyloid peptides in experimental models of Alzheimer's disease.
Purdue’s role in the center will be to facilitate characterizations of grape/wine extracts and determine the bioavailability, metabolism and distribution of polyphenols to target tissues.
For more information, contact Dr. Mario Ferruzzi, firstname.lastname@example.org; or Dr. Elsa Janle, email@example.com.