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Educational Background - B.S., Nutrition at Oregon State University in 1972
- M.S., Nutrition at Oregon State University in 1974
- Ph.D., Nutrition at Florida State University in 1978
Dissertation Title- Uptake and effects of processing of nuclear fision products in vegetables
Awards & Honors - Herbert Newby McCoy Award from Purdue University, 2012 - Present
- Member Institute of Medicine from National Academy of Science, 2010 - Present
- Gilbert A. Leveille Lectureship Award from ASN/IFT, 2011
- Linus Pauling Research Award from Oregon State University, 2011
- Membership from Institute of Medicine, 2010
- Burton Kallman Scientific Award from National Products Association, 2010
- ASN Robert H Herman Award from American Society for Nutrition, 2009
- Harris Award from Ohio State University, 2008
- Foods and Nutrition Hall of Fame from Purdue University, 2006
- Sigma Xi Faculty Research Award from Sigma Xi, 2006
- Career Award from American College of Nutrition, 2005
- Centennial Laureate Award from Florida State University, 2005
- W. O. Atwater Lecturership from Agricultural Research Service, USDA and American Society for Nutritional Sciences, 2003
- Distinguished Professor of Foods and Nutrition from Purdue University, 2000
Activities & Memberships - Member (Editorial Board) from American Society for Bone and Mineral Research, 1989 - Present
- Member (Food and Nutrition Board) from Institute of Medicine, National Academy of Science, 2010
- Member (Past President) from American Society for Nutrition, 1999
- Member (Fellow) from American College of Nutrition, 1995
- Member (Purdue Chapter) from Sigma Xi, 1978
- Member (Member) from Institute of Food Technologists, 1978
Discovery - Our laboratory studies calcium metabolism during lifestages of high demand, i.e., building peak bone mass during adolescence and bone loss in postmenopausal women. Calcium needs in adolescence is investigated with metabolic research camps (Camp Calcium). Calcium balance is determined as well as calcium kinetics using stable isotopic tracers, total body calcium and bone mineral density using dual energy x-ray absorptiometry, and biochemical markers of bone turnover. Our goal is to determine the influence of diet, gender, actual calcium retention and maximize development of peak bone mass. We are also studying the relationship between dairy and calcium intake and body fat maintenance in this population.
Dietary alternatives to estrogen replacement therapy for postmenopausal women are also being investigated in our laboratory. by a novel approach of Ca-41 technology. Osteoporosis is a disease characterized by decreased skeletal mass and increased susceptibility to bone fractures. The health care costs related to hip fracture alone exceed $17 billion per year in the U.S. Two strategies to prevent osteoporosis includes increasing bone mass early in life and to prevent loss later. We hope to be able to give dietary and exercise advice to help women prevent osteoporosis later in life.
The chemical form of minerals in foods and bioavailability of minerals from foods has been a theme of study in our laboratory for many years. We use isotopic tracer techniques to intrinsically label foods or salts of interest in order to study factors which enhance or inhibit absorption and their biological fate in animal models or humans. We have screened many food sources for calcium bioavailability. We have developed rat models for studying calcium kinetics and bone strength. Evaluating enhancers and inhibitors of calcium absorption by active and passive routes is our focus of one laboratory.
Discovery Publications - Weaver CM, Alekel DL, Ward WE, Ronis MJ. Flavonoid intake and bone health. J Nutr Gerontol Geriatr 31-239-253, 2012.
- Rosanoff A, Weaver Cm, Rude RK. Suboptimal magnesium status in the United States: are the health consequences underestimated? Nutr Rev 70(3):153-164, 2012.
- Hill KM, Laing EM, Hausman DB, Acton A, Martin BR, McCabe GP, Weaver CM, Lewis RD, Peacock M. Bone turnover is not influenced by serum 25-hydroxyvitamin D in pubertal healthy black and white children. Bone 51:595-799, 2012.
- Hill KM, Jonnalagadda SS, Albertson AM, Josh NA, Weaver CM. Top Food Sources Contributing to Vitamin D Intake and the Association of Ready-to-Eat Cereal and Breakfast Consumption Habits to Vitamin D Intake in Canadians and United States Americans J Food Sci 77:H170-H175, 2012.
- Legette LL, Lee WH, Martin BR, Story JA, Campbell JK, Weaver CM. Enhance Magnesium Absorption and Inulin-based Fibers Exert Chronic Effects on Calcium Utilization in a Postmenopausal Rodent Model. J Food Sci 77:89-94, 2012.
- Lee W-H, Wastney M E, Jackson GS, Martin BR, Weaver CM. Interpretation of 41Ca data using compartmental modeling in post-menopausal women. Anal Bioanal Chem. 399:1613-1622, 2011.
- Hohman EE, Martin BR, Lachcik PJ, Gordon DT, Fleet JC, Weaver CM. Bioavailability and Efficacy of Vitamin D2 from UV—irradiated yeast in growing, Vitamin D-deficient rats. Agri Food Chem 56:2341-2346, 2011.
- O’Connell DN, Weinheimer EM, Martin BR, Weaver CM, Campbell WW. Water turnover assessment in overweight adolescents. Obesity 19:292-297, 2011.
- Cheong J, Gunaratna N, McCabe G, Jackson G, Kempa-Steczko A, Weaver C. Bone seeking labels as markers for bone turnover: Validation of urinary excretion in rats. Osteoporosis Intl. 22:153-157, 2011.
- Hill KM, Braun MM, Egan KA, Martin BR, McCabe LD, Peacock M, McCabe GP, Weaver CM. Obesity augments calcium-induced increases in skeletal calcium retention in adolescents. J Clin Endocrinol Metab 96:2171-7, 2011. PMID21490075
- Eicher-Miller HA, Mason AC, Weaver CM, McCabe GP, Boushey CJ. Food insecurity is associated with diet and bone mass disparities in early adolescent males but not females in the United States. J Nutr 111:1-8, 2011.
- Elble AE, Hill KM, Park CY, Martin BR, Peacock M, Weaver CM. Effect of calcium carbonate particle size on absorption and retention in adolescent girls. J Am Col Nutr 30:171-177, 2011
- Weaver CM, Campbell WW, Teegarden D, Craig BA, Martin BR, Singh R, Braun MM, Apolzan J, Hannon TS, Schoeller DA, DiMeglio L, Hickey Y, Peacock M. Calcium, dairy products, and energy balance in overweight adolescents: A controlled trial. Am J Clin Nutr 94:1163-1170, 2011. DOI: 10.3945/ajcn.110.010264
- Zhang Q, Wastney ME, Rosen CJ, Beamer WG, Weaver, CM. Insulin-like growth factor I increases bone calcium accumulation only during rapid growth in female rats. J Nutr. 141: 2010-6, 2011.
- Adamec J, Kannasch A, Huang J, Hohman E, Fleet JC, Peacock M, Ferruzzi MG, Martin B, Weaver CM. Development and optimization of an LC-MS/MS based method for simultaneous quantification of vitamin D2, vitamin D3, 24-hydroxyvitamin D2 and 25-hydroxyvitamin D3. J Sep Sci. 34(1): 11-20, 2011.
- Osborne DL, Weaver CM, McCabe LD, McCabe GM, Novotny R, Boushey C, Savaiano DA. Tanning predicts bone mass but not structure in adolescent females living in Hawaii. Am J Hum Biol. 23(4): 470-8, 2011.
- Weaver CM, Martin BR, Nakatsu CH, Armstrong AP, Clavijo A, McCabe LD, McCabe GP, Duignan S, Schoterman MG, van den Heuvel EG. Galactooligosaccharides improve mineral absorption and bone properties in growing rats through gut fermentation. J Agric Food Chem. 59(12): 6501-10, 2011.
- Legette LL, Lee WH, Martin BR, Story JA, Arabshahi A, Barnes S, Weaver CM. Genistein, a phytoestrogen, improves total cholesterol, and Synergy, a prebiotic, improves calcium utilization, but there were no synergistic effects. Menopause 18(8): 923-31, 2011.
- Weaver CM, Campbell WW, Teegarden D, Craig BA, Martin BR, Singh R, Braun MM, Apolzan J, Hannon TS, Schoeller DA, DiMeglio L, Hickey Y, Peacock M. Calcium, dairy products, and energy balance in overweight adolescents: A controlled trial. Am J Clin Nutr 94:1163-1170, 2011.
- Lee W, McCabe GP, Martin BR, Weaver. Validation of a simple isotope method for estimating true calcium fraction absorption in adolescents. Osteoporos Int 22(1):159-166, 2011.
Books, Chapters & Monograph Publications - Rowe S, Alexander N, Aldeida N, Black R, Burns R, Bush L, Crawford P, Keim N, Kris-Etherton P, Weaver C. Foods Science Challenge: Translating the Dietary Guidelines for Americans to bring about real behavior change. J Food Sci. 76, NR.1, 2011.
- Weaver CM, Peacock, M. Calcium. Advances in Nutrition: An International Review Journal. 2:290-292, 2011.
- NAMS 2011 Isoflavone Report The role of soy isoflavones in menopausal health: report of The North American Menopausa Society/Wulf H. Utian Translational Science Symposdium in Chicago, IL Menopause 18(7):1-22, 2011.
- Weaver CM, Lewis RD, Laing EM. Ch 4. Vitamin D in skeletal growth and development. In: Translational Endocrinology & Metabolism: Vitamin D Update. Eds. Robertson RP, Demay MB. The Endocrine Society 2(3):43-60, 2011
- Holick, MF, Binkley, NC, Birschoff-Ferrari, HA, Gordon, CM, Hanley, DA, Heaney, R P, Murad, MH, Weaver, CM. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society Clinical Practice Guideline. J Clin Endocrin Metab 96:1911-30, 2011.
- Park, CY, Weaver, CM. Calcium and Bone Health: Influence of Prebiotics. Functional Food Reviews 3:62-72, 2011.
- Rowe S, Alexander N, Almeida NG, Black R, Burns R, Bush L, Crawford P, Keim N, Kris-Etherton P, Weaver CM. Translating the dietary guidelines for Americans 2010 to bring about real behavior change. J Amer Diet Assoc 111: 28-39, 2011. DOI: 10.1016/j.jada.2010.11.007.
- Rowe S, Alexander N, Almeida NG, Black R, Burns R, Bush L, Crawford P, Keim N, Kris-Etherton P, Weaver CM. Food science challenge: Translating the dietary guidelines for Americans to bring about real behavior change. J Food Science 00: R1-R9. DOI: 10.1111/j.1750-3841.2010.01973.x.
- Weaver CM. Chapter 28: Calcium for Present Knowledge in Nutrition, 10th Ed. Erdman, J.
- Weaver CM, Lewis RD, Laing EM. Ch 37. Adolescence and Acquisition of Peak Bon Mass. In: Vitamin D, Third Ed., Elsevier, Inc. Eds. D. Feldman, JW. Pike, JS Adams. Academic Press Pg, 657-677, 2012.
- Alekel LD, Weaver CM, Ronis MJJ. Bioactive Food as Dietary Interventions for Arthritis and Related Inflammatory Diseases. In: Nutritional Influences on Bone Health and Overview of Methods, Watson RR, ed. Elsevier Limited. Oxford, United Kingdom. Pp., 2013.
Learning FN 40000
| Executive in the Classroom: Lecture and discussion, featuring industrial and business executives in food-related areas. Emphasis is placed on careers in the food industry.
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FN 59000
| Basic Bone Biology
This course is intened to rpovide the fundamental elements of bone biology to graduate students interested in musculoskeletal biology.
Topics willinclude:
• Cellular/molecular regulation of bone cells
• Tissue composition and regulation by remodeling
• Bone imaging
• Fracture healing
• Biomaterials
• Mineral homeostasis
• PTH, sex steroid, systemic hormone effects on bone
• Metabolic bone diseases
• Nutrition/Exercise/Pharmaceutical effects on bone
• Cancer effects on the bone
• Skeletal genetics
Students will also learn how to critically evaluate the scientific literature through a series of journal club presentations. | | | (Fall) |
FN 60500
| Nutritional Biochemistry and Physiology I: The course goal is to provide a foundation in the scientific concepts relevant to nutrient metabolism and nutrient-disease interaction. Dr. Weaver contributes lectures on metabolism methodology and calcium.
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Learning Publications - Weaver, C.M. and Daniel, J.D. The Food Chemistry Laboratory: A Manual for Experimental Foods, Dietetics, and Food Scientists, Vol. 16, ISBN 0849312930 CRC Press, Boca Raton, FL 2003.
- Charley, H. and Weaver, C.M. FOODS: A Scientific Approach. 3rd Ed. Prentice-Hall, Inc. Upper Saddle River, NJ 1998 Pp. 581 ISBN: 0-02-321951-3.
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