Elsa M. Janle, PhD

Associate Research Professor

Foods and Nutrition

Contact Information

Purdue University
700 West State St.
West Lafayette, IN 47907-2059
Phone: (765) 494-1566
Fax: (765) 494-0906
E-mail: janle@purdue.edu

Education Background

  • B.S. in Chemistry at Ursinus College in 1963
  • M.S. in Organic Chemistry at Purdue University in 1965
  • Ph.D. in Physiology at Purdue University in 1980
  • Post-Doc. in Insulin Receptors at Indiana University School of Medicine in 1982

Dissertation Title: Experimental Diabetes in Dogs: I. Effects of Pancreatic Tissue Implants, II. Plasma Osmolality Following Glucose Infusion

Awards and Honors

  • 2000 Space Act Award, NASA

Discovery

My major interest is diabetes and glucose control. To monitor glucose in diabetics without removal of blood, I developed the ultrafiltrate probe. The ultrafiltrate probe is a membrane probe which can be implanted in subcutaneous tissue. A negative pressure is applied and interstitial fluid is removed. These probes can be used for long term monitoring in large or small animal models. I have also worked on additional uses of the ulrafiltrate probe for other areas of medical research including measurement of bone minerals in bone, muscle and subcutaneous tissue.

In the area of botanicals, I am investigating the effects of green tea on glucose tolerance in Zucker diabetic rats.

As a member of the Bioanalytical Cores of the Botanical Center for Age Related Diseases and the Centers of Excellence project to study the Protective Effects of Grape Polyphenols in the Prevention of Alzheimer's Disease, I work with other investigators in these centers to study the bioavailabiliy of botanical compouds in animal models. A major focus of this investigation is the determination of the potential of compounds, which might be beneficial in prevention of Alzheimer's disease, to cross the blood-brain barrier.

Discovery Publications (selected)

Weaver CM., Barnes S, Wyss JM, Helen Kim, Dorothy M. Morré, D. James Morré, James E. Simon, Mary Ann Lila, Elsa M. Janle, Mario G. Ferruzzi. Botanicals for age related diseases: from field to practice. American Journal of Clinical Nutrition: 87: 493S-497S

Janle EM, Morré DM, Morré DJ, Zhou Q, Zhu Y. Pharmacokinetics of Green Tea Catechins in Extract and Sustained Release Preparations. Journal of Dietary Supplements 5:248-63

Janle E, Sojka J, Jackson GS, Lachcik P, Santerre CR. Measuring Transfer of 14C-PCB from Maternal Diet to Milk in a Goat Model Using an Accelerator Mass Spectrometer (AMS). Nuclear Instruments and Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms 259: 758-762, 2007.

Janle EM, Portocarrero C, Zhu Y, Zhou Q. Effect of Long-Term Oral Administration of Green Tea Extract on Weight Gain and Glucose Tolerance in Zucker Diabetic (ZDF) Rats. Journal of Herbal Pharmacotherapy 5: 55-64, 2005.

Janle EM, Cregor M Sojka J. Interstitial Fluid Calcium, Magnesium and Phosphorus Concentrations in Bone, Muscle and Subcutaneous Tissue Sampled with Ultrafiltration Probes. Current Separations 19: 37-41, 2001

Janle EM, Sojka J. Use of Ultrafiltration Probes in Sheep to Collect Interstitial Fluid for Measurement of Calcium and Magnesium. Contemporary topics in Laboratory Animal Science, 39: 46-50, 2000.

Janle EM, Kissinger PT: Monitoring physiological variables with membrane probes. Acta Astronautica, 43: 87-99, 1998.

Janle EM, Ostroy S, Kissinger P: Monitoring the Progress of Streptozotocin Diabetes in the Mouse with the Ultrafiltration Probe. Current Separations 11: 17-19, 1992.

Janle-Swain E, Van Vleet J, Ash SR: Use of a Capillary Filtrate Collector for Monitoring Glucose Levels in Diabetics. American Society of Artificial Internal Organs Transactions 33: 336-340, 1987.

Janle-Swain E, Jackson HD, Roesel OF, Bottoms G: Improvement in Glucose Tolerance of Diabetic Dogs after Implantation of Neonatal Pancreatic Fragments. Pancreas 1: 24-28, 1986.

Books, Chapters, and Monographs Publications

Janle EM, Kissinger PT: Microdialysis and Ultrafiltration in Advances in Nutrition, 40, 183-196, Academic Press, 1996.

Janle-Swain E: Animal Models of Diabetic Nephropathy in Handbook of Animal Models for Renal Failure, Ash SR and Thornhill JA, Eds., CRC Press, Boca Raton, 1985.

Learning

Courses

Nutrition and Cancer (F&N 590C) This course examines the nature of cancer and the interaction between individual nutrients and cancer risk. The course relies on the discussion of primary literature.

Nutritional Biochemistry and Physiology I (F&N 605) - Its goal is to provide a foundation in the scientific concepts relevant to nutrient metabolism and nutrient-disease interaction. Topics covered in this semester include: cell biology of the intestine, nutrient transport, carbohydrate metabolism, and mineral metabolism.

Nutrition and Genetics (F&N 590G - special topics) - The goal of this course is to examine the general principles governing the genetic contributions to complex diseases and to review literature that indicates that diet or lifestyle factors can modify genetic susceptability to disease. The course relies on the discussion of primary literature.

Nutrition and Genomics (F&N 590 - special topic) This course examines how the information from the human genomic project is influencing our understanding of cell biology and molecular diagnostics. We focus on examples that are relevant to nutrition science by using examples from the primary literature.

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