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Elsa M. Janle,  Ph.D.
Associate Research Professor
Foods and Nutrition

Purdue University
700 West State St.
West Lafayette, IN 47907-2059
Phone: (765)494-1566
Fax: (765)494-0906
Email: janle@purdue.edu

EDUCATION BACKGROUND

  • B.S. in Chemistry at Ursinus College in 1963
  • M.S. in Organic Chemistry at Purdue University in 1965
  • Ph.D. in Physiology at Purdue University in 1980
  • Post-Doc. in Insulin Receptors at Indiana University School of Medicine in 1982

  • Dissertation Title: Experimental Diabetes in Dogs: I. Effects of Pancreatic Tissue Implants, II. Plasma Osmolality Following Glucose Infusion

    AWARDS AND HONORS

    2000  Space Act Award   NASA

    DISCOVERY

    My major interest is diabetes and glucose control. To monitor glucose in diabetics without removal of blood, I developed the ultrafiltrate probe. The ultrafiltrate probe is a membrane probe which can be implanted in subcutaneous tissue. A negative pressure is applied and interstitial fluid is removed. These probes can be used for long term monitoring in large or small animal models. I have also worked on additional uses of the ulrafiltrate probe for other areas of medical research including measurement of bone minerals in bone, muscle and subcutaneous tissue.

    In the area of botanicals, I am investigating the effects of green tea on glucose tolerance in Zucker diabetic rats.

    As a member of the Bioanalytical Cores of the Botanical Center for Age Related Diseases and the Centers of Excellence project to study the Protective Effects of Grape Polyphenols in the Prevention of Alzheimer's Disease, I work with other investigators in these centers to study the bioavailabiliy of botanical compouds in animal models. A major focus of this investigation is the determination of the potential of compounds, which might be beneficial in prevention of Alzheimer's disease, to cross the blood-brain barrier.

    Discovery Publications (selected)


    Peters CM, Green RJ, Janle E, Ferruzzi MG. Formulation with ascorbic acid and sucrose modulates catechin bioavailability from green tea. Food Research International 43: 95-102, 2010.

    Mun JG, Grannan M, Lachcik P, Reppert A, Yousef GG, Rogers RB, Janle EM, Weaver CM, Lila MA. Metabolic Tracking of 14C-labeled Isoflavones. British Journal of Nutrition 9: 1-8, 2009

    Weaver C, Barnes S, Wyss JM, Kim H, Morre D, Morre J, Simon J, Lela MA, Janle E, Ferruzzi M. Research Highlights from the Purdue-UAB BotanicalsResearch Center for Age Related Diseases. Pharmaceutical Biology. 47: 768-773, 2009

    Ho L, Chen LH, Wang J, Zhao W, Talcott ST, Ono K, Teplow D, Humala N, Cheng A, Percival SS, Ferruzzi M, Janle E, Dickstein DL, Pasinetti GM. Heterogeneity in red wine polyphenolic contents differentially influences Alzheimer’s disease-type neuropathology and cognitive deterioration. J Alz. Dis: 16: 59-72, 2009Nuclear Instruments and Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms 259: 758-762, 2007.

    Ferruzzi MG, Lobo JK, Janle E, Cooper B, Simon JE, Wu Q-L, Welch C, Ho L, Weaver C, Pasinetti GM. Bioavailability of gallic acid and catechins from grape seed polyphenol extract is improved by repeated dosing in rats: implications for treatment of Alzheimer’s Disease. Journal of Alzheimer’s Disease 18: 113-24, 2009.

    Weaver CM, Janle E, Martin BR, Browne S, Guiden H, Lachcik P. Dairy vs. Calcium Carbonate in Promoting Peak Bone Mass and Bone Maintenance During Subsequent Calcium Deficiency. JBMR. 24: 1411-19, 2009.

    Neilson AP, George JC, Janle EM, Mattes RiD, Ralf R, Matusheski NV, Ferruzzi MG. Influence of Chocolate Matrix Composition on Cocoa Flavan-3-ol Bioaccessibility In Vitro and Bioavailability in Humans. J Agric Food Chem. 57: 9418-26, 2009

    Janle EM, Morré DM, Morré DJ, Zhou Q, Zhu Y. Pharmacokinetics of Green Tea Catechins in Extract and Sustained Release Preparations. Journal of Dietary Supplements 5:248-63

    Weaver CM., Barnes S, Wyss JM, Helen Kim, Dorothy M. Morré, D. James Morré, James E. Simon, Mary Ann Lila, Elsa M. Janle, Mario G. Ferruzzi. Botanicals for age related diseases: from field to practice. American Journal of Clinical Nutrition: 87: 493S-497S

    Shim S-M, Ferruzzi M, Kim Y-C, Janle EM, Santerre SR. Impact of phytochemical-rich foods on bioaccessibility of mercury from fish. Food Chem, 112: 46-50, 2008.


    Books, Chapters, and Monographs Publications


    Janle EM, Kissinger PT: Microdialysis and Ultrafiltration in Advances in Nutrition, 40, 183-196, Academic Press, 1996.

    Janle-Swain E: Animal Models of Diabetic Nephropathy in Handbook of Animal Models for Renal Failure, Ash SR and Thornhill JA, Eds., CRC Press, Boca Raton, 1985.

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    Contact Information

    Foods and Nutrition
    Purdue University
    700 W. State Street
    West Lafayette, IN
    47907-2059

    Phone: (765) 494-8228
    Fax: (765) 494-0674
    E-mail: fandn@purdue.edu

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