Elsa M. Janle, Ph.D. Associate Research Professor Foods and Nutrition
Purdue University 700 West State St. West Lafayette, IN 47907-2059 Phone: (765)494-1566 Fax: (765)494-0906 Email: janle@purdue.edu
EDUCATION BACKGROUND
B.S. in Chemistry at Ursinus College in 1963
M.S. in Organic Chemistry at Purdue University in 1965
Ph.D. in Physiology at Purdue University in 1980
Post-Doc. in Insulin Receptors at Indiana University School of Medicine in 1982
Dissertation Title: Experimental Diabetes in Dogs: I. Effects of Pancreatic Tissue Implants, II. Plasma Osmolality Following Glucose Infusion
AWARDS AND HONORS
2000
Space Act Award
NASA
DISCOVERY
My major interest is diabetes and glucose control. To monitor glucose in diabetics without removal of blood, I developed the ultrafiltrate probe. The ultrafiltrate probe is a membrane probe which can be implanted in subcutaneous tissue. A negative pressure is applied and interstitial fluid is removed. These probes can be used for long term monitoring in large or small animal models. I have also worked on additional uses of the ulrafiltrate probe for other areas of medical research including measurement of bone minerals in bone, muscle and subcutaneous tissue.
In the area of botanicals, I am investigating the effects of green tea on glucose tolerance in Zucker diabetic rats.
As a member of the Bioanalytical Cores of the Botanical Center for Age Related Diseases and the Centers of Excellence project to study the Protective Effects of Grape Polyphenols in the Prevention of Alzheimer's Disease, I work with other investigators in these centers to study the bioavailabiliy of botanical compouds in animal models. A major focus of this investigation is the determination of the potential of compounds, which might be beneficial in prevention of Alzheimer's disease, to cross the blood-brain barrier. Discovery Publications (selected)
Peters CM, Green RJ, Janle E, Ferruzzi MG. Formulation with ascorbic acid and sucrose modulates catechin bioavailability from green tea. Food Research International 43: 95-102, 2010.
Mun JG, Grannan M, Lachcik P, Reppert A, Yousef GG, Rogers RB, Janle EM, Weaver CM, Lila MA. Metabolic Tracking of 14C-labeled Isoflavones. British Journal of Nutrition 9: 1-8, 2009
Weaver C, Barnes S, Wyss JM, Kim H, Morre D, Morre J, Simon J, Lela MA, Janle E, Ferruzzi M. Research Highlights from the Purdue-UAB BotanicalsResearch Center for Age Related Diseases. Pharmaceutical Biology. 47: 768-773, 2009
Ho L, Chen LH, Wang J, Zhao W, Talcott ST, Ono K, Teplow D, Humala N, Cheng A, Percival SS, Ferruzzi M, Janle E, Dickstein DL, Pasinetti GM. Heterogeneity in red wine polyphenolic contents differentially influences Alzheimer’s disease-type neuropathology and cognitive deterioration. J Alz. Dis: 16: 59-72, 2009Nuclear Instruments and Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms 259: 758-762, 2007.
Ferruzzi MG, Lobo JK, Janle E, Cooper B, Simon JE, Wu Q-L, Welch C, Ho L, Weaver C, Pasinetti GM. Bioavailability of gallic acid and catechins from grape seed polyphenol extract is improved by repeated dosing in rats: implications for treatment of Alzheimer’s Disease. Journal of Alzheimer’s Disease 18: 113-24, 2009.
Weaver CM, Janle E, Martin BR, Browne S, Guiden H, Lachcik P. Dairy vs. Calcium Carbonate in Promoting Peak Bone Mass and Bone Maintenance During Subsequent Calcium Deficiency. JBMR. 24: 1411-19, 2009.
Neilson AP, George JC, Janle EM, Mattes RiD, Ralf R, Matusheski NV, Ferruzzi MG. Influence of Chocolate Matrix Composition on Cocoa Flavan-3-ol Bioaccessibility In Vitro and Bioavailability in Humans. J Agric Food Chem. 57: 9418-26, 2009
Janle EM, Morré DM, Morré DJ, Zhou Q, Zhu Y. Pharmacokinetics of Green Tea Catechins in Extract and Sustained Release Preparations. Journal of Dietary Supplements 5:248-63
Weaver CM., Barnes S, Wyss JM, Helen Kim, Dorothy M. Morré, D. James Morré, James E. Simon, Mary Ann Lila, Elsa M. Janle, Mario G. Ferruzzi. Botanicals for age related diseases: from field to practice. American Journal of Clinical Nutrition: 87: 493S-497S
Shim S-M, Ferruzzi M, Kim Y-C, Janle EM, Santerre SR. Impact of phytochemical-rich foods on bioaccessibility of mercury from fish. Food Chem, 112: 46-50, 2008.
Books, Chapters, and Monographs Publications
Janle EM, Kissinger PT: Microdialysis and Ultrafiltration in Advances in Nutrition, 40, 183-196, Academic Press, 1996.
Janle-Swain E: Animal Models of Diabetic Nephropathy in Handbook of Animal Models for Renal Failure, Ash SR and Thornhill JA, Eds., CRC Press, Boca Raton, 1985.
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Contact Information
Foods and Nutrition Purdue University 700 W. State Street West Lafayette, IN 47907-2059
