John (Jay) R. Burgess, PhD
Foods and Nutrition
700 W. State Street
West Lafayette, IN 47907-2059
Phone: (765) 494-8239
Fax: (765) 494-0906
- B.S. in Biology/Biochemistry at Pennsylvania State University in 1980
- M.S. in Nutrition at Pennsylvania State University in 1985
- Ph.D. in Nutrition at Pennsylvania State University in 1988
- Post-Doc. in Pharmacology at University of California at Santa Barbara in 1990
Dissertation Title: Arachidonic Acid Cascade: Studies on the Cyclooxygenase Pathway
Oxidative stress, defined by the accumulation of reactive oxygen species (ROS), is implicated in the development of many chronic and degenerative diseases as well as some psychological disorders. ROS accumulation damages cellular macromolecules and can lead to loss of polyunsaturated fatty acids (PUFA) and endogenous antioxidants. In the Burgess lab we have been studying the role of oxidative stress and omega-3 fatty acid status in attention-deficit/hyperactivity disorder (ADHD) for a number of years. This work has involved studies in humans and animals. We have shown that a subpopulation of children with ADHD exhibit PUFA imbalances which may result from oxidative stress. Further work, in an animal model of ADHD, showed that supplemental treatment with the antioxidant nutrient vitamin E reversed brain PUFA deficits, elevated blood and brain antioxidant status to control levels, and improved behavior. We have also been studying whether flavonoid antioxidants exhibit this function in vivo. In this work, conducted in rodents, we have shown that although flavonoid compounds like naringenin and epigallocatechin gallate (EGCG) exhibit very good peroxyl-radical scavenging antioxidant activity in vitro, they are unable to compensate for deficiency of the essential antioxidant nutrients vitamin E and selenium. However, our studies with EGCG in vivo are suggestive of a synergy with vitamin E which has been previously proposed. A current research effort is focused on the role of oxidative stress in the complications of diabetes and the potential for dietary antioxidants to ameliorate these complications. Studies are underway in a diabetes animal model and in cells representing peripheral neurons which are susceptible to the complications of diabetes. We also continue to pursue studies to determine the relationship between oxidative stress, antioxidant nutrient intake and omega-3 fatty acid status in children and young adults with behavioral disorders.
Discovery Publications (selected)
Andrade, J. E. and J. R. Burgess (2007). "Effect of the citrus flavanone naringenin on oxidative stress in rats." J Agric Food Chem 55(6): 2142-8.
Nanua, S., S. M. Zick, J. E. Andrade, U. S. Sajjan, J. R. Burgess, N. W. Lukacs and M. B. Hershenson (2006). "Quercetin blocks airway epithelial cell chemokine expression." Am J Respir Cell Mol Biol 35(5): 602-10.
Guo, Q., B. T. Richert, J. R. Burgess, D. M. Webel, D. E. Orr, M. Blair, G. E. Fitzner, D. D. Hall, A. L. Grant and D. E. Gerrard (2006). "Effects of dietary vitamin E and fat supplementation on pork quality." J Anim Sci 84(11): 3089-99.
Cabo, R., J. R. Burgess and P. Navas (2006). "Adaptations to oxidative stress induced by vitamin E deficiency in rat liver." J Bioenerg Biomembr 38(5-6): 309-17.
Antalis, C. J., L. J. Stevens, M. Campbell, R. Pazdro, K. Ericson and J. R. Burgess (2006). "Omega-3 fatty acid status in attention-deficit/hyperactivity disorder." Prostaglandins Leukot Essent Fatty Acids 75(4-5): 299-308.
Begum, R., M. A. Belury, J. R. Burgess and L. W. Peck (2004). "Supplementation with n-3 and n-6 polyunsaturated fatty acids: effects on lipoxygenase activity and clinical symptoms of pruritus in hemodialysis patients." J Ren Nutr 14(4): 233-41.
Stevens, L., Zhang, W., Peck, L., Kuczek, T., Grevstad, N., Mahon, A., Zentall, S.S., Arnold, L. E., and J. R. Burgess (2003) Polyunsaturated fatty acid supplementation in children with inattention, hyperactivity and other disruptive behaviors. Lipids 38:1007-1021.
Stedman, L., Nickel, K. P., Castillo, S. S., Andrade, J., Burgess, J. R. and D. Teegarden (2003) 1,25-dihydroxyvitamin D3 inhibits Vitamin E succinate-induced apoptosis in C3H10T1/2 Cells but not Harvey ras-transfected cells . Nutrition and Cancer 45(1):93-100.
Andrade, J., and J. R. Burgess (2002) Effect of dietary flavonoid antioxidants on vitamin E and selenium deficiency in rats. FASEB J. 16(5):A1009.
Braun, C.M., Burgess, J. R. and M.A. Latour (2001) Liver lipid accumulation in duck embryos and hatchlings changes with parental age. Biol. Neonate 80:228-234.
Books, Chapters, and Monographs Publications
Burgess, J. R. and J. E. Andrade (2006). Antioxidant Effects of Citrus Flavonoid Consumption. Potential Health Benefits of Citrus. B. S. Patil, E. G. Miller, N. D. Turner and J. S. Brodbelt. Washington, DC, An American Chemical Society Publication.
Burgess, J.R. & Steven, L. Essential fatty acids in relation to attention-deficit/hyperactivity disorder: An update. Phospholipid Spectrum Disorders in Psychiatry II (Glen, Peet, & Horrobin, eds.) Marius Press, U.K., 2003.
Burgess, J.R. and F. Gao (2002) The Antioxidant effects of inositol phosphates. In: Food Phytates (Eds. Reddy, N. R. and Sathe, S.K.) CRC Press, Boca Raton, FL.
Stevens, L. and J. R. Burgess (1999) Essential fatty acids in children with attention-deficit/hyperactivity disorder. In: Phospholipid Spectrum Disorder in Psychiatry (Eds. Peet, M., Glenn, I, and Horrobin, D.F.) Pp. 263-269. Marius Press, Lancashire, UK.
Essentials of Nutrition (F&N 303) - Basic principles of nutrition and their application in meeting nutritional needs during the life cycle.
Nutrition Assessment (F&N 436) - Nutrition assessment in humans including anthropometric, biochemical, clinical, and dietary assessment.
Phytochemial Biochemistry and Physiology (F&N 590F) - Advanced study of the biochemistry and physiology of phytochemicals focusing on bioavailability and potenital health benefits.
Lipid Regulation of Cell Function (F&N 590L) - Advance study of the role of lipids in the regulation of cell function.