F&N 435 - Nutrition, Metabolism
Fall,
2002
M F
2:30, W 230‑4:20
BRNG B268
Dr. D.M. Morré Teaching Assistant:
Stone Hall G-1E Kader Yagiz
Office Tel.: 494-8233 Stone Hall G-32 (494-8794)
E-mail: morred@cfs.purdue.edu yagiz@purdue.edu
Course Objectives: The overall objective will be to understand the theories and principles of metabolism and to apply them to human nutrition. The specific aims will be the following:
¨ To become familiar with cell constituents, cell components and membrane compartments and their functions
¨ To outline hormones/enzymes involved in digestion, absorption and metabolism of major nutrients -- carbohydrates, lipids and proteins
¨ To relate the chemical structure and biochemical function of the water-soluble vitamins and their metabolites and antagonists to their regulatory role in metabolism
¨ To describe how the functions and forms of fat-soluble vitamins affect their utilization
¨ To understand how water distribution, electrolyte and fluid balance and regulation of pH are involved in homeostatic maintenance important to human nutrition
A packet prepared by Dr. Morré containing copies of many of the overheads used in the course is required and should be brought to class to use during the lectures. The packet is available at the book stores.
Suggested Text Groff,
J.L. and Gropper, S.S. 1999. Advanced Nutrition and Human Metabolism. West Publishing Co.,
Prerequisites: F&N 315 and BCHM 307 & 309 (or equivalent). Since this is an advanced nutrition course, it will be assumed that you have a sound background in the biological sciences, particularly biochemistry and physiology.
Date Topic Pages
Overview
of metabolism
Aug. 19 Introduction to metabolism: Methods and approaches to
understanding metabolism
Aug. 21-28 The cell and its components: structure, uniqueness of membranes 1 - 23
and brief discussion of function(s)
Plasma membrane
Nucleus, endoplasmic reticulum and Golgi apparatus
Mitochondrion
Cytoplasm and cytoplasmic matrix
Lysosomes and peroxisomes
Aug. 28 (Wednesday) QUIZ
1
Aug. 28 -30 Selected cells – erythrocyte, liver, and kidney -- brief overview
Sept. 2 NO CLASS--LABOR DAY
Sept. 4-6 Digestion & Absorption: Anatomical structures, 24 - 52 Hormones, Enzymes, Regulatory Mechanisms
Sept. 9 (Monday) QUIZ 2
MACRONUTRIENTS
AND THEIR METABOLISM
Sept. 9-16 Carbohydrates: Structural functions, classifications, digestion 70 - 79
absorption, transport and regulation
Dietary Fiber 106 –122
Integrated metabolism in tissues: 85 - 89
Glycolysis,
High, energy phosphate bond, formation of ATP, 57 -59
(substrate level phosphorylation)
Pentose Phosphate Shunt
Glycogenesis
Sept. 18 (Wednesday) EXAMINATION I
Sept. 20-27 Glycogenolysis 83-84
Gluconeogenesis 94-95
Krebs Cycle
Oxidative phosphorylation and electron transport chain 59-69
Sept. 30 (Monday) QUIZ 3
Dr. Young-Cheul Kim is
responsible for the lipids section Stone Hall G-1A, Office Tel: 496-2626, E-mail:yckim@cfs.purdue.edu
Sept. 30 – Oct. 4 Lipids: Classifications, nomenclature, structure and functions, 123 - 162
digestion and absorption, transport.
Integrated metabolism in tissues, role of the liver and adipose tissue
in lipid metabolism
Synthesis of fatty acid
Synthesis of triglycerides, phospholipids and cholesterol
Oct 4 (Friday) QUIZ 4
Oct. 7 NO CLASS – OCTOBER BREAK
Oct. 9-11 Fatty acid oxidation
Formation of ketone bodies
Catabolism of cholesterol
Oct. 11-18 Proteins: Functional categories: enzymes, peptide hormones, structural 163 - 219
and transport proteins
Amino acid classification (specific structures will be the students’ responsibility)
Basic structure and organization: Primary, secondary, tertiary and quaternary structure
Digestion and absorption
Regulation of amino acid metabolism (possible fates of absorbed amino acids)
Protein synthesis (brief discussion) and regulation
Organ-specific metabolism, Protein quality
Oct. 16 (Wednesday) EXAMINATION II
REGULATORY NUTRIENTS
Oct. 21-25 Water-soluble vitamins: Chemistry, biochemical function, 245 - 315
metabolites, antagonists
Thiamin,
Riboflavin, Niacin and Vitamin B6
Oct. 28 (Monday) QUIZ 5
Dr. Kim lectures
Oct.
28 – Nov. 4 Pantothenic acid, Folate, Vitamin
B12, Biotin,
Ascorbate Some of the pseudovitamins
Nov. 6 (Wednesday) QUIZ 6
Nov. 6-11 Fat-soluble vitamins: Chemistry, biochemical functions, 316-370
metabolites, absorption and transport
Vitamin A and Vitamin D
Nov. 13 (Wednesday) EXAMINATION
III
Nov. 15-18 Fat-soluble vitamins
(continued) Vitamin E and Vitamin K
HOMEOSTATIC MAINTENANCE
Nov. 18 Distribution of water, maintenance of electrolyte and fluid balance, 423-438
Regulation of pH. Minerals: Digestion and absorption
Nov. 20-22 Minerals (continued): transport, functions and regulation of interactions
with other nutrients, deficiency, toxicity and assessment of nutriture
Macrominerals: Calcium and phosphorus, magnesium, sodium, 371-400
potassium, chloride and sulfur
Nov. 25 (Monday) QUIZ 7
Nov. 27-29 NO CLASS – THANKSGIVING BREAK
Dec. 2-6 Selected Microminerals: Iron, iodine, manganese, zinc, copper, 401- 470 selenium and others
Dec. 6 Hypermetabolic states
Dec. 9-14 Final Examination week
There will be 7 (20 min) quizzes
worth 20 points each that will be given at the beginning of the respective
class period. Since the 5 quizzes with
the highest scores will be used in computing your final grade NO MAKE-UP QUIZZES WILL BE GIVEN UNDER ANY CIRCUMSTANCES. If you are forced to miss an examination due
to unforeseeable circumstances,
contact Dr. Morré or Dr. Kim PRIOR to the time of the examination. If Dr. Morré is not available, leave a
message that includes the reason for your absence and how you may be
contacted. You will be required to
provide a written excuse (i.e.,
physician’s note, accident report, etc.) before a makeup exam will be
given. If you know that you will miss an
exam beforehand and have a valid written excuse, arrangements will be made to
take the exam early. Students who have not made arrangements
with Dr. Morré to take the make-up examination according to the above
guidelines will be without an examination grade and will receive zero for that examination.
Keep up with the course. Class Participation is an integral part of the course since it keeps you alert and helps others in the course. You are expected to participate in discussion. There may be times when you will be asked to go in front of the class to help with review sessions. Help sessions outside of the class time will be scheduled for your benefit so take advantage of them and attend. We will spend additional time with you if you have questions. Working one-on-one with us is a good way for us to get to know you better and for you to know us. However, Kader’s role in the course is as a teaching assistant which means that she is prohibited from serving the role of a tutor for the course. If you feel that you need a tutor, please ask Dr. Morré for contact information.
Attendance is not mandatory for a grade but it is highly suggested that you plan to attend every lecture. Quizzes and examinations will be based on material presented in class and the text is considered supplementary. Students who frequently skip class should not expect the instructor (nor the teaching assistant) to give make-up classes or provide special help. If it is necessary to miss a lecture, arrange to get notes from someone in the class. There will be extra handouts available that you can get from Kader. If you have questions or concerns, please feel free to contact Dr. Morré, Dr. Kim or Kader by e-mail. We check our e-mail each day, but do not always have time to respond immediately.
Letter
Grade Points
Examinations I, II & III @ 100 points. . . . . . . 300 A 567-630
Final Examination (Comprehensive). . . . . . . . 200 B 504-566
Quizzes (total of 5 @ 20 points each). . . . . . . 100 C 441-503
Feedback*. . . . . . . . . . . . . . . . . . . . . . . . . . . .. 30 D 378-440
Total . . . . . . . . . . . . . . 630 F < 378
Examinations and quizzes will be graded and the results returned to the students as soon as available.
*Feedback: During the last few minutes of some of the class periods, you will be requested to write brief comments over the major concepts/areas that were covered that day as well as what, if any, parts you were having difficulty understanding. The request will be announced at the beginning of class on the respective day.
Regrading: Contested questions will be regraded when accompanied by a written statement indicating how the answer given matches the answer found in an authoritative source (not the internet nor another instructor’s lecture notes). The source must be referenced; preferably, a photocopy of the pertinent material should be attached to the written statement. Regrades will not be considered once final grades are submitted at the end of the semester.
This course will be taught in compliance with the University Policies pertaining to prejudice and cheating as stated in "University Regulations".